Knowledge Base

Duke Criteria for Infective Endocarditis

Diagnosis requires one of the following:

  • 2 major criteria
  • 1 major and 3 minor criteria
  • 5 minor criteria
Major Criteria:
  • Positive blood cultures for IE
  • Evidence of endocardial involvement
Minor Criteria:
  • Predisposition
  • Fever > 38.0°C
  • Vascular Phenomena
  • Immunologic phenomena
  • Microbiologic evidence
Additional Reading
Reference Download
Journal Article
Kang, D., Kim, Y., Kim, S., et al. Early surgery versus conventional treatment for infective endocarditis. The New England Journal of Medicine 2012, June: 366 (26). 		Download Paper
Clinical Review Article:
Hoen, B., Duval, X. Clinical practice. Infective endocarditis. The New England journal of medicine 2013, April: 368 (15). 		Download Paper